Trimovate Cream

Trimovate Cream can be ordered from our UK registered online prescribing service. Simply complete an online medical questionnaire as part of your order. This helps our prescribers make sure it is safe and suitable to prescribe for you. 

If approved by our medical team, our pharmacy team will receive a prescription. This will be dispensed and dispatched to your delivery address. Only people currently prescribed this by their GP can request this medicine.

Trimovate cream is a triple action treatment for skin conditions containing three active ingredients, one is a steroid called Clobetasone, an antibiotic called Oxytetracycline and Nystatin which is an antifungal agent.

Trimovate combines clobetasone, oxytetracycline and nystatin in a cream form to help combat dry skin conditions such as eczema/dermatitis which may also be infected.

The three active ingredient in Trimovate cream work in different ways to help with skin conditions that are itchy, inflamed and may get infected.

Clobetasone butyrate is a type of medicine called a topical corticosteroid that is used to reduce inflammation in the skin. It works inside the skin cells to stop the release of inflammatory substances that cause swelling, redness and itching. Clobetasone is a moderate strength corticosteroid.

Oxytetracycline is an antibiotic medicine used to treat infections with bacteria. It works by preventing bacteria from producing proteins that are essential to them. Without these proteins the bacteria cannot grow, replicate and increase in numbers.

Nystatin is an antifungal medicine that kills fungi and yeasts such as Candida by interfering with their cell membranes.

This combination cream is prescribed for treating moist areas of inflamed skin where bacterial or Candidal infection is already present or suspected, or is likely to occur, such as nappy rash, seborrhoeic dermatitis, or inflamed areas where skin surfaces are in contact for example between the thighs or between the buttocks. This type of skin inflammation is referred to as impetigo.

Trimovate can be used to treat many conditions of the skin where a bacterial or fungal infection is also confirmed or suspected. These include but are not limited to –

• Dermatitis (atopic, discoid, stasis, contact or seborrheic)
• Eczema
• Psoriasis
• Nappy rash
• Impetigo (inflammation caused by skin to skin friction)

Trimovate contains a stronger steroid product compared to hydrocortisone, but not as strong as Betnovate (betamethasone) or Dermovate (clobetasol).

Trimovate is formulated to be applied topically to the affected skin only.

The cream should be applied sparingly to the affected area, taking care not to get too much on the surrounding healthy skin. Application of the cream is usually once or twice a day until the condition has improved. Once the symptoms have settled, treatment should be stopped or switched to a less potent preparation.

Continuous treatment with Trimovate should be for no longer than seven days. If you have not seen any improvement in your condition within this timeframe, or if your symptoms worsen, then this should be reviewed by your GP. Patients need to allow enough time for the cream to be absorbed before applying any other emollient. If the cream is being applied to an area other than the hands, then patients need to make sure they wash their hands thoroughly after each application.

Trimovate can be used in all age groups including children and the elderly. The cream should always be used in accordance with the prescribers instructions.

Renal/Hepatic Impairment – if applying the cream to a large surface area where systemic absorption may occur, then metabolism and excretion may be delayed which may lead to increased possibility of toxicity. Care should be taken when using in this patient group (short duration and minimum quantity).

You should not use Trimovate if you:

• Have a known allergy to any of the active ingredients or any of the excipients of the cream
• Have a primary viral infection of the skin
• Have primary skin lesions which could be a result of a bacterial, fungal or yeast infection
• Have a confirmed skin infection caused by Acinetobacter species, methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas species, Proteus species Serratia species or Streptococcus B
• Are trying to treat rosacea or acne with Trimovate.
• Have itchy skin without any inflammation.

Depending on site of administration, systemic absorption is possible. Special care should be taken to avoid any contact with the eyes or the area surrounding the eyes. Other factors which may contribute towards systemic absorption include:

• How long the drug treatment is likely to be
• If you are applying the cream to a large surface area
• Use on thin skin such as the face
• Use on broken skin
• Occlusion